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Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 87-96 doi: 10.15302/J-FASE-2016087

Abstract: In the present study, follistatin ( ) gene expression vectors with either a bicistronic gene transfercassette alone, or a bicistron gene cassette carrying a matrix attachment region (MAR) were constructedpMAR-FST vector, which excluded the resistant genes and frame structure, enhances and stabilizes gene

Keywords： safety of transgenic     bicistron gene transfer body     transgenic mice     muscle development    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed LentivirusWestern blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantlyLentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 4,   Pages 360-366 doi: 10.1007/s11465-013-0280-8

Abstract:

Mobile concrete pump boom is typical multi-body large-scale motion manipulator.A dynamics model of a mobile concrete pump boom is established based on discrete time transfer matrixThe overall dynamic equation and transfer matrix of the model can be assembled by sub-structures A and

Keywords： multi-body     mobile concrete pump boom     discrete time transfer matrix method (DTTMM)     kinematic     dynamic     tip    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achievedin liver-directed gene transfer mediated by adeno-associated viral vectors.vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B geneIn addition, the regulatory elements that control the FIX gene expression in these cassettesreconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Bacteriophages in water pollution control: Advantages and limitations

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1378-y

Abstract:

•Phages can be better indicators of enteric viruses than fecal indicator bacteria.

Keywords： Phage     Water pollution monitoring     Harmful bacteria biocontrol     Horizontal gene transfer     Bacterial resistance    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 251-261 doi: 10.1007/s11684-019-0727-3

Abstract: Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreatic body

Keywords： pancreatic fistula     pancreatic body and tail resection     distal pancreatectomy    

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Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1136-1

Abstract:

• Quantitative global ARGs profile in dialysis water was investigated.

• Totally 35 ARGs were found in the dialysis treatment train.

• 29 ARGs (highest) were found in carbon filtration effluent.

• erm and mtrD-02 occurred in the final effluent.

• The effluent was associated with health risks even after RO treatment.

Keywords： Dialysis water     Treatment process     Antibiotic resistance gene     High-throughput quantitative PCR     Horizontalgene transfer    

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Laboratory experiment on using non-floating body to generate electrical energy from water waves

Arunachalam AMARKARTHIK, Srinivasan CHANDRASEKARAN, Karuppan SIVAKUMAR, Harender SINHMAR

Frontiers in Energy 2012, Volume 6, Issue 4,   Pages 361-365 doi: 10.1007/s11708-012-0210-1

Abstract: This paper describes an innovative method of using a non-buoyant body to harness ocean waves.The present study shows that using a non-buoyant body for conventional point absorber principle is muchA small scale wave energy converter with non-buoyant body was designed, fabricated and tested in small

Keywords： ocean wave energy     point absorbers     heaving body     non-floating object     heave response ratio     electrical energy    

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Lightweight design of an electric bus body structure with analytical target cascading

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0718-y

Abstract: In this study, a lightweight design of a newly developed multi-material electric bus body structure is

Keywords： electric vehicle     body in white (BIW)     lightweight     analytical target cascading (ATC)    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: Polymer-based conjugates are an interesting option and challenge for the design of nano-sized drug-delivery systems, as they require advanced conjugation chemistry and precise engineering. In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the delivery process, namely 1) protection of the cargo from extracellular degradation, 2) avoidance of non-specific interactions with non-targeted tissues, 3) efficient entry into the target cells, 4) intracellular trafficking to the site of action and 5) cargo release. To take on these obstacles, multifunctional conjugates can act as “smart polymers” with microenvironment-sensing dynamics to facilitate the separate delivery steps. Synthesis of defined polymer architectures with precise functionalization enables structure-activity relationships to be investigated and the integration of key functions for efficient delivery. Thus bioresponsive polymer conjugates, which are equipped with molecular devices responding to the certain microenvironments within the delivery pathway (e.g. pH, redox potential, enzymes) can be assembled. This review focuses on the modular engineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic acid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Yesterday, Today and Future of the Engineering Management Body of Knowledge

Hiral Shah,Walter Nowocin

Frontiers of Engineering Management 2015, Volume 2, Issue 1,   Pages 60-63 doi: 10.15302/J-FEM-2015009

Abstract: The purpose of engineering management body of knowledge (EMBOK) is to delineate the knowledge, skills

Keywords： body of knowledge     engineering management     certification exam     engineering manager     competency areas    

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Thinking About Establishing New Medicine

Ma Ainai,Zhao Shaoqui

Strategic Study of CAE 2007, Volume 9, Issue 10,   Pages 19-23

Abstract:  But it always cures illness by dissevering human body. So Western medicine has puzzled itself about how to stick up for whole human body.uniform to systemic theory" ,  advance to establish a new medicine,  that is "Human Body

Keywords： complexity science     open complex giant system     human body ecosystem     human body information system     humanbody ecological medicine    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 339-351 doi: 10.1007/s11684-022-0943-0

Abstract: -3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting enzyme in ketogenesis, to promote ketone bodyThe data suggests that SB activated HMGCS2 through SIRT5-mediated desuccinylation for ketone body productionThe data provide a novel molecular mechanism for SB activity in the induction of ketone body production

Keywords： sodium butyrate     succinylation     HMGCS2     ketogenesis     SIRT5    

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Title Author Date Type Operation

Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

A dynamic model of mobile concrete pump boom based on discrete time transfer matrix method

Wu REN, Yunxin WU, Zhaowei ZHANG

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Bacteriophages in water pollution control: Advantages and limitations

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Journal Article

Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Journal Article

Laboratory experiment on using non-floating body to generate electrical energy from water waves

Arunachalam AMARKARTHIK, Srinivasan CHANDRASEKARAN, Karuppan SIVAKUMAR, Harender SINHMAR

Journal Article

Lightweight design of an electric bus body structure with analytical target cascading

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Yesterday, Today and Future of the Engineering Management Body of Knowledge

Hiral Shah,Walter Nowocin

Journal Article

Thinking About Establishing New Medicine

Ma Ainai,Zhao Shaoqui

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation

Journal Article